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目的观察硒对家兔心肌缺血再灌注损伤(IRI)膜磷脂的保护作用。方法 24只家兔,雌雄各半,随机分成假手术组、缺血再灌注组、硒组,分别检测心肌组织中总磷脂(PL)、总胆固醇(Ch)、磷脂酰乙醇胺(PE)、心磷脂(CL)含量。结果缺血再灌注组与假手术组比较,缺血再灌注组PL、PE、CL含量(41.21±9.71、415.30±31.25、200.56±29.41)明显降低(P<0.05),Ch含量(88.75±14.03)明显升高(P<0.05)。硒组与缺血再灌注组比较,硒组PL、PE、CL含量(58.73±11.12、764.34±51.87、325.79±31.14)明显升高(P<0.05),硒组Ch含量(62.41±12.11)明显降低(P<0.05)。结论硒对家兔心肌缺血再灌注损伤膜磷脂有保护作用。
Objective To observe the protective effect of selenium on membrane phospholipid in myocardial ischemia-reperfusion injury (IRI) in rabbits. Methods Twenty-four rabbits were randomly divided into sham operation group, ischemia reperfusion group and selenium group. The total phospholipid (PL), total cholesterol (Ch), phosphatidylethanolamine (PE) Phospholipid (CL) content. Results The contents of PL, PE and CL in ischemia-reperfusion group were significantly lower than those in sham operation group (41.21 ± 9.71,415.30 ± 31.25,200.56 ± 29.41, P <0.05), and Ch (88.75 ± 14.03 ) Was significantly higher (P <0.05). The contents of PL, PE and CL in selenium group (58.73 ± 11.12,764.34 ± 51.87,325.79 ± 31.14) were significantly higher than those in ischemia-reperfusion group (P <0.05), and those in selenium group (62.41 ± 12.11) Decreased (P <0.05). Conclusion Selenium has a protective effect on membrane phospholipid of myocardial ischemia-reperfusion injury in rabbits.