在胞内寄生原虫中,恶性疟原虫仅感染无蛋白和脂类生物合成活性的红细胞,弓形虫能侵入各种具有蛋白和脂类合成功能的有核细胞。它们都寄生于宿主细胞质中的纳虫空泡(PV)内,虫体与宿主细胞的胞质间形成一膜性界面,并通过纳虫空泡膜(PVM)进行物质代谢如营养摄入等。本文作者研究了宿主细胞膜的通透性对胞内寄生虫代谢、生存能力的影响。 In intracellular parasites, Plasmodium falciparum infects only erythrocytes that are free of protein and lipid biosynthesis, and Toxoplasma gondii can invade a variety of nucleated cells that have synthetic protein and lipid functions. They are both parasitic in the host cytoplasm of the pars nano-vacuoles (PV), which form a membrane-bound interface with the host cell cytoplasm and carry out material metabolism such as nutrient ingestion through the nematopoietic vacuolar membrane (PVM) . The authors studied the effects of host cell membrane permeability on intracellular parasite metabolism and viability.