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目的:探讨顺德区大良社区妇女液基细胞学检查(LCT)联合高危型人乳头瘤病毒(HPV)分型检测在宫颈癌筛查中的结果及健康教育措施。方法:选取2013年3月至2015年5月参与HPV和LCT检查的妇女作为研究对象,一共1000例,采用PCR-反向斑点杂交检测技术对19种高危型HPV-DNA进行检测,使用液基细胞学检测仪检测LCT。结果:HPV灵敏度90.31%、特异度25.21%,LCT灵敏度62.50%、特异度86.55%,并联灵敏度96.36%高于单项检测灵敏度,差异具有统计学意义(P<0.05)。结论:LCT联合高危型HPV分型检测敏感、快速且准确,优于单独的LCT检测或高危型HPV分型检测,对于大规模宫颈癌筛查具有较好应用价值,另外应对HPV阳性者进行进一步分型检测分流措施,以提高宫颈癌的筛查准确率。
Objective: To investigate the results of LCT and HPV genotyping among women in Daliang Community in Shunde District for cervical cancer screening and health education measures. Methods: A total of 1000 women with HPV and LCT from March 2013 to May 2015 were enrolled. A total of 1000 women were screened for high-risk HPV-DNA using PCR-reverse dot blot hybridization. Liquid-based Cytology detector LCT. Results: The sensitivity of HPV was 90.31%, specificity was 25.21%, LCT sensitivity was 62.50%, specificity was 86.55%, sensitivity of parallelism was 96.36% higher than single detection sensitivity, the difference was statistically significant (P <0.05). Conclusion: LCT combined with high-risk HPV typing is sensitive, rapid and accurate, which is superior to LCT alone or high-risk HPV genotyping. It is of value in large-scale screening of cervical cancer, and should be further applied to HPV-positive patients Split detection of sub-type measures to improve the screening of cervical cancer accuracy.