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利用磁控溅射技术在组装整齐的微球表面依次镀上银、金薄膜,获得双金属纳米壳层结构。以对巯基苯胺(p-ATP)为探针分子,研究了该壳层结构在不同激发线下SERS增强差异。测试结果表明,金银双金属纳米壳层结构在780nm激光下具有很好的SERS增强效果,并随着外层金膜厚度的减小而逐渐增强。对各个基底的增强因子进行计算可知,基底的表面等离子体共振(SPR)峰与激发线的匹配程度越好,其增强因子越大。由于金的高稳定性和良好的生物相容性,该基底在SERS生物传感方面具有很大应用潜力。
Using magnetron sputtering technique, silver and gold thin films are sequentially plated on the surface of the assembled microspheres to obtain a bimetallic nanoshell structure. Using p-ATP as a probe, the enhancement of SERS in the shell structure under different excitation lines was studied. The test results show that the gold-silver bimetallic nanoshell structure has a good SERS enhancement effect under the 780nm laser and gradually increases as the thickness of the outer gold film decreases. Calculating the enhancement factor of each substrate shows that the match between the surface plasmon resonance (SPR) peak of the substrate and the excitation line is better, and the enhancement factor is larger. Due to the high stability of gold and good biocompatibility, the substrate has great potential for SERS biosensing.