IL-6对B 细胞分化和免疫球蛋白的分泌有调节作用,过去已有许多报导,但多数研究是用肿瘤细胞或体外诱导活化B 细胞的方法进行的。用各种不同的抗原免疫正常人,在血循环中可短暂出现B 淋巴母细胞(LBB),这些细胞在体内已活化并开始分化,所以为研究B 细胞成熟后期提供了一个有用的模型。本文即研究IL-6在LBB细胞体外自发产生抗体中的作用。 IL-6 plays a regulatory role in the differentiation of B cells and the secretion of immunoglobulins, and many reports have been made in the past. However, most studies have used tumor cells or induced activation of B cells in vitro. Immunization of normal individuals with a variety of different antigens may lead to the transient appearance of B lymphoblasts (LBBs) in the blood circulation, which have been activated and begin to differentiate in vivo and therefore provide a useful model for studying the later stages of B cell maturation. This article investigates the role of IL-6 in the spontaneous production of antibodies in LBB cells in vitro.