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许多固体药物,在药剂生产过程中或贮存时,外观常呈现湿润甚至液化,其原因大多是由于生成共熔混合物或吸附水蒸气所致。兹分别简述如下。固体药物的共熔许多分子间引力微弱的药物,如三甲双酮、乙琥胺、3-乙基-5-苯基海因、氨基比林、安替比林、非那西丁、氨茶碱、咖啡因、阿司匹林、薄荷脑、樟脑、水合氯醛、抗坏血酸等,两种或更多种进行混合时,常由于混合物的熔点及湿润点降低,在室温下即呈现湿润甚至液化。这些药物混合物湿润或液化的程度,主要取决于混合物的组成及温度,其间关系通常是用相图来表示。以下仅就二组分体系,按组分间生成分子化合物与否两种情况,予以分述。
Many solid drugs, in the pharmaceutical production process or storage, the appearance of often wet or liquefied, mostly due to the formation of eutectic mixture or adsorption of water vapor. The briefing is respectively as follows. Eutectic solid drug Many intermolecular weakly gravitational drugs, such as metformin, ethylsuccinate, 3-ethyl-5-phenylhydantoin, aminopyrine, antipyrine, phenacetin, ammonia tea Alkali, caffeine, aspirin, menthol, camphor, chloral hydrate, ascorbic acid and the like. When two or more are mixed, the melting point and the wetting point of the mixture are often lowered and wet or liquefied at room temperature. The degree to which these drug compounds wet or liquefy depends primarily on the composition and temperature of the mixture, the relationship between which is usually indicated by the phase diagram. The following only two-component system, according to the molecular compounds generated between the two cases or not, be divided.