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目的观察剖宫产患者术后应用理想抗生素进行预防性治疗的临床效果。方法对我院自2006年11月至2011年11月以来,于我科行剖宫产的642例患者在术后应用抗生素的临床资料进行回顾性分析,将其分为ABCD四组,A组446例予以青霉素与甲硝唑治疗,B组112例予以氧哌嗪青霉素治疗,C组24例予以克林霉素治疗,D组60例予以先锋V治疗。结果 A组患者术后体温达到正常的时间是(52.8±25.5)h,B组是(48.5±25.7)h,C组是(51.5±23.8)小时,D组是(61.8±50.7)h,D组同其他组相较,术后体温的恢复时间较长,差异有统计学意义(P<0.01);B组患者用药费用与产褥病率同A组相较,差异无统计学意义(P>0.05),并且药物的不良反应较低。结论剖宫产患者术后应用青霉素与甲哨唑进行预防性治疗仍然为首选方案,但氧哌嗪青霉素也值得进行临床推广,而对青霉素有过敏者,其抗生素选择则有限,需进行更进一步的探讨。
Objective To observe the clinical effect of prophylactic treatment with ideal antibiotics after cesarean section. Methods The clinical data of 642 patients who underwent cesarean section in our hospital from November 2006 to November 2011 were retrospectively analyzed after antibiotics were divided into four groups ABCD, 446 cases were treated with penicillin and metronidazole, 112 cases in group B were treated with piperacillin, 24 cases in group C were treated with clindamycin, and 60 cases in group D were treated with vanguard V. Results The postoperative body temperature of group A was (52.8 ± 25.5) h, group B was (48.5 ± 25.7) h, group C was (51.5 ± 23.8) hours, group D was (61.8 ± 50.7) h, D Compared with other groups, the postoperative recovery time of body temperature was longer, the difference was statistically significant (P <0.01). The cost of medication and the rate of puerperal in group B were not significantly different from those in group A (P > 0.05), and the adverse drug reaction is low. Conclusions Postoperative penicillin and metoprolol for postoperative prophylaxis are still the preferred regimen, but piperacillin is also worthy of clinical promotion, while those who are allergic to penicillin have limited antibiotic selection and need to go one step further Discussion.