论文部分内容阅读
目的探讨乳汁HBV-DNA阳性产妇母乳喂养的安全性。方法乳汁HBV-DNA阳性产妇117例(双胞2例),119例幼儿出生时均接受HBV主动+被动免疫,自由选择喂养方式,其中母乳喂养34例(母乳喂养组),人工喂养85例(人工喂养组),观察两组幼儿慢性感染HBV情况。结果 119例幼儿慢性感染HBV34例,慢性感染率为28.57%;其中母乳喂养组幼儿慢性感染率为32.35%(11/34),人工喂养组为27.06%(23/85),差异无统计学意义(P>0.05);但幼儿HBV慢性感染组与未感染组母亲乳汁HBV-DNA水平差异有统计学意义(P<0.05)。结论幼儿慢性感染HBV与产妇乳汁HBV-DNA载量有关,但母乳喂养并未增加感染HBV的风险。
Objective To investigate the safety of breast milk-fed HBV-DNA positive mothers. Methods A total of 117 breast-positive HBV-DNA positive mothers (2 twin) were enrolled in this study. 119 babies born at the time of birth were given active and passive immunization with HBV. Feeding mothers were randomly selected. Breastfeeding was performed in 34 (breastfeeding group) and 85 Artificial feeding group), two groups of young children infected with chronic HBV infection. Results A total of 119 children were chronically infected with HBV and the rate of chronic infection was 28.57%. Among them, the rate of chronic infection in infants was 32.35% (11/34) in breastfeeding group and 27.06% (23/85) in artificial feeding group, with no significant difference (P> 0.05). However, there was a significant difference in serum HBV-DNA level between mothers with chronic HBV infection and those without infection (P <0.05). Conclusions Chronic HBV infection in young children is related to HBV-DNA load in maternal milk, but breastfeeding does not increase the risk of HBV infection.