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目的观察米索前列醇引产的临床效果。方法将本院2005年1月至2007年7月有引产指征的足月妊娠孕妇115例随机分成两组,研究组60例,以米索前列醇50μg放置于阴道后穹窿引产,平卧0.5h,放置24h后未临产再放置50μg,累计100μg;对照组55例,予催产素2.5IU加入5%葡萄糖液500ml中静脉滴注,根据宫缩情况调节速度,直至调出有效宫缩,对两组引产成功率和分娩情况进行比较。结果研究组宫颈促成熟效果明显优于对照组(P<0.01),研究组用药至临产时间显著短于对照组(P<0.01),引产成功率高于对照组。结论米索前列醇是一种安全有效的促宫颈成熟和引产药物,用药安全简便,值得临床广泛推广。
Objective To observe the clinical effect of misoprostol induction of labor. Methods From January 2005 to July 2007, 115 pregnant women of full-term pregnancy who had induced labor induction were randomly divided into two groups. The study group consisted of 60 patients. Misoprostol 50μg was placed in vaginal fornix after vaginal abortion, lying 0.5 h, placed after 24h non-labor and then placed 50μg, a total of 100μg; control group of 55 patients, to give oxytocin 2.5IU 5% glucose solution 500ml intravenous infusion, according to the contractions adjust the speed until the effective contractions transferred, the right The success rate of induction of labor and delivery between the two groups were compared. Results The cervical ripening effect was significantly better in the study group than in the control group (P <0.01). The study group was significantly shorter than the control group (P <0.01). The success rate of induction of labor was higher than that of the control group. Conclusion Misoprostol is a safe and effective method to promote cervical ripening and induction of labor. It is safe and easy to use and should be widely popularized clinically.