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目的 探讨环氧化酶 -2 (COX -2 )在食管癌中的表达情况及其与淋巴结转移的关系。方法 应用免疫组织化学方法(SP法 ) ,检测 1999～ 2 0 0 1年手术切除的 76例食管癌病人中COX -2的表达。其中有食管旁淋巴结转移者 18例 ,胃左动脉旁淋巴结转移者 11例。结果 COX -2在食管癌中的表达率为 81 6 %,主要为癌组织的表达 ,而在癌旁组织几乎不表达 ;食管癌旁和胃左动脉旁淋巴结转移组COX -2的表达水平均高于未转移组 (P <0 0 0 1)。结论 食管癌中COX -2的高度表达与食管癌的发生、发展及淋巴结转移有关 ,提示COX -2可能是防治食管癌的一个靶位。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) in esophageal cancer and its relationship with lymph node metastasis. Methods Immunohistochemistry (SP method) was used to detect the expression of COX-2 in 76 patients with esophageal cancer who were surgically removed from 1999 to 2001. Among them, there were 18 cases of esophageal lymph node metastasis and 11 cases of gastric left-sided lymph node metastasis. Results The expression of COX-2 in esophageal carcinoma was 81.6%, which was mainly expressed in cancerous tissues and almost not in paracancerous tissues. The expressions of COX-2 in para-carcinoma and para-gastric lymph nodes Higher than the non-metastasis group (P <0 0 0 1). Conclusion The high expression of COX-2 in esophageal cancer is related to the occurrence and development of esophageal cancer and lymph node metastasis, suggesting that COX-2 may be a target of prevention and treatment of esophageal cancer.