图像配准是图像分析和处理的基本问题，在医学影像、遥感遥测、计算机视觉等领域有着广泛的应用。基于边缘提取和利用Ｆｏｕｒｉｅｒ变换和Ｍｅｌｉｎ变换，本文提出了估计医学图像之间的配准参数的新方法。文中的计算机模拟结果表明，这种方法非常适合多模态医学影像处理。 Image registration is the basic problem of image analysis and processing. It has a wide range of applications in medical imaging, telemetry and computer vision. Based on the edge extraction and the use of Fourier transform and Melin transform, this paper presents a new method to estimate the registration parameters between medical images. Computer simulation results show that this method is very suitable for multi-modality medical image processing.