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目的 通过测定慢性乙肝患者的血清、尿液 β2 微球蛋白 ,确定血、尿 β2 微球蛋白在慢性乙肝早期肾功能损害中的价值。方法 对 60例慢性乙肝患者提取血和尿样 ,测定 β2 MG、血BUN和Cr。血、尿 β2 MG采用免疫比浊法 ,BUN采用脲酶法 ,Cr采用苦味酸法 ,在TBA 3 0FR型全自动生化分析仪编程测定。结果 血清ALT增高的慢性乙肝患者、尿 β2 MG和正常体检者相比差异非常显著 (P <0 .0 1) ,而其血BUN、Cr差异无显著性 (P >0 .0 5 )。结论 血、尿 β2 BG具有较好的早期肾损害诊断价值。临床上仅以BUN、Cr作为慢性乙肝患者的肾功能损害指标是不够的 ,应常规检测血、尿 β2 MG来判断肝脏损伤程度及预测肝肾综合征的发生具有重要意义。
Objective To determine the value of serum and urinary β2 microglobulin in the early stage of chronic hepatitis B with impaired renal function by measuring serum and urine β2 microglobulin in chronic hepatitis B patients. Methods Blood and urine samples were collected from 60 patients with chronic hepatitis B. The levels of β2 MG, blood BUN and Cr were measured. Blood, urine β2 MG using immune turbidimetry, BUN urease, Cr picric acid method, TBA30FR automatic biochemical analyzer programming. Results Compared with normal subjects, there was a significant difference in urinary β2 MG levels between patients with chronic hepatitis B and those with normal serum ALT levels (P <0.01). There was no significant difference in serum BUN and Cr between the two groups (P> 0.05). Conclusion Blood and urine β2 BG have better diagnostic value of early renal damage. Clinically only BUN, Cr as indicators of renal damage in patients with chronic hepatitis B is not enough, should be routine testing blood and urine β2 MG to determine the extent of liver damage and predict the occurrence of hepatorenal syndrome is of great significance.