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目的探讨特异性免疫治疗(Allergen-specific immunologic therapy:ASIT)对慢性鼻窦炎(chronic rhinosinusitis:CRS)伴常年性变应性鼻炎患者行功能性鼻窦内窥镜手术(functional endoscopic sinus surgery:FESS)预后干预作用。方法采用随机分组方法将确诊慢性鼻窦炎伴常年性变应性鼻炎患者随机分成两组,治疗Ⅰ组:FESS+术后ASIT组;治疗Ⅱ组:FESS组。分别对两组患者进行术前、术后6个月、术后一年症状及体征评分并进行对比,采用鼻腔鼻窦结局测量20条(SNOT-20),鼻内镜(Lund-kennedy)评分法及CT(Lund-mackay)评分法。结果两组患者术后6个月及一年SNOT-20量表的20个条目总分与5大条目总分指标均有明显好转(P<0.05),但两组间存在显著性差异,治疗Ⅰ组疗效优与治疗Ⅱ组。结论特异性免疫治疗可减少慢性鼻窦炎术后复发,改善预后。
Objective To investigate the effect of Allergen-specific immunologic therapy (ASIT) on the prognosis of functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis (CRS) and perennial allergic rhinitis Intervention. Methods Randomly divided patients with chronic rhinosinusitis and perennial allergic rhinitis were randomly divided into two groups, treatment group Ⅰ: FESS + postoperative ASIT group; treatment Ⅱ group: FESS group. The two groups of patients were preoperatively, 6 months after surgery, one year after surgery symptoms and signs were compared, compared with the nasal sinus outcome measured 20 (SNOT-20), endoscopic (Lund-kennedy) score And CT (Lund-mackay) score method. Results The total scores of 20 items and 5 items in the SNOT-20 scale at 6 months and one year after operation in both groups were significantly improved (P <0.05), but there was significant difference between the two groups in treatment Ⅰ group curative effect and treatment group Ⅱ. Conclusion Specific immunotherapy can reduce postoperative recurrence of chronic sinusitis and improve prognosis.