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细胞外基质不仅维持着体内细胞微环境的稳定,还在细胞的正常生长、增殖以及细胞之间的信号传导中起着重要作用。肿瘤发生时,基质中的分子组分发生了改变,这些改变朝着有利于肿瘤细胞生长侵袭的方向发展。在这个过程中,细胞外基质的主要成分在合成和分解上发生巨大变化,胶原分子便是其中之一,胶原分子作为细胞外基质中的主要成分,对细胞的黏附、运动、迁移等活动起着重要作用。随着研究的深入,发现越来越多的胶原分子参与了肿瘤的发生发展。基质中还存在着一些分子,它们在结构上和胶原蛋白一样含有三螺旋胶原结构域,在肿瘤的发生发展过程中同样发挥着重要作用。本文就包括胶原分子在内的含有胶原结构的分子在肿瘤中的作用做一综述。
The extracellular matrix not only maintains the stability of the cell microenvironment in vivo, but also plays an important role in the normal cell growth, proliferation and signal transduction between cells. When tumors occur, the molecular components in the matrix change, and these changes move in the direction of favoring tumor cell growth and invasion. In this process, the major components of the extracellular matrix undergo dramatic changes in synthesis and decomposition. Collagen molecules are one of them. Collagen molecules, as the major components in the extracellular matrix, play an important role in the adhesion, movement and migration of cells An important role. With the deepening of research, more and more collagen molecules were found involved in the development of tumors. There are also some molecules in the matrix, which have the same three-helix collagen structure as collagen and play an important role in the development and progression of tumors. This article reviews the role of collagen-containing molecules, including collagen molecules, in oncology.