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应用抗人胎盘型谷眈甘肽S-转移酶（GST-л）切单克隆抗体，ABC免疫组化染色，检测59例食管癌（包括鳞癌57例，腺癌2例）组织中的GST－л表达，阳性率为88.14％，且这种GST－л阳性染色与鳞癌的分化程度呈正相关。而视为癌前病变的食管上富不典型增生7例GST－л阳性率为57.14％（4／7）；10例正常食管上皮GST－л染色均为阴性。研究表明GST－л是食管癌及其癌前病变有用的标志酶。
Anti-human placental glutathione S-transferase (GST-л) was used to excise monoclonal antibody and immunohistochemical staining with ABC. GST was detected in 59 cases of esophageal cancer (including squamous cell carcinoma in 57 cases and adenocarcinoma in 2 cases). -л expression, the positive rate was 88.14%, and this GST-л positive staining was positively correlated with the degree of differentiation of squamous cell carcinoma. The positive rate of GST-л in 7 patients with atypical hyperplasia in the esophagus treated as precancerous lesions was 57.14% (4/7); GST-л staining was negative in 10 cases of normal esophageal epithelium. Studies have shown that GST-л is a useful marker enzyme for esophageal cancer and its precancerous lesions.