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近年来,许多报告提示NK细胞对于恶性肿瘤的发生、增殖可能起重要作用.但NK细胞,特别是人NK细胞对肿瘤细胞的作用尚无定论;NK细胞在体内是否真的控制癌的发生和增殖仍不明确.近年,笔者曾对有白血病前兆患者的NK细胞进行了动态观察,获得了饶有兴趣的发现.本文拟介绍癌前状态及生癌时NK细胞在体内的作用,从而对人NK细胞的抗肿瘤作用加以探讨.NK细胞的抗肿瘤作用以往曾认为抗肿瘤增殖的免疫防御主要是T淋巴细胞,但越来越多的报告认为未必如此.在T淋巴细胞功能缺陷而保留有NK细胞活性的裸鼠,仍显示有对同系或同种的移植肿瘤的抵抗力.亚同系A、F_1杂交小鼠
In recent years, many reports have suggested that NK cells may play an important role in the occurrence and proliferation of malignant tumors. However, the role of NK cells, especially human NK cells, in tumor cells has not been conclusive; whether NK cells actually control the occurrence of cancer in vivo and Proliferation is still unclear. In recent years, I have performed dynamic observations of NK cells in patients with leukemia precursors and obtained interesting findings. This article is intended to introduce the role of NK cells in the preneoplastic state and in vivo cancer, thus The anti-tumor effects of NK cells are discussed. Anti-tumor effects of NK cells In the past, it was thought that the immune defense against tumor proliferation is mainly T lymphocytes, but more and more reports do not think so. In T lymphocyte function defects are retained NK cell-activated nude mice still show resistance to syngeneic or homogeneous transplanted tumors. Syngeneic A, F_1 hybrid mice