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目的:评价复方甲硝唑栓与结合雌激素软膏联用对老年性阴道炎患者的临床疗效。方法:选取2014年4月—2016年4月期间医院收治的老年性阴道炎患者100例,按随机双色球分组法将其分为对照组和治疗组,每组50例;对照组患者给予复方甲硝唑栓治疗,治疗组患者在对照组治疗的基础上加用结合雌激素软膏治疗,评价两组患者治疗后的总有效率和临床症状各项评分值(采用Donders评分系统、阴道健康评分与评估阴道脱落细胞成熟指数值)和激素水平如FSH(卵泡刺激素)和E2(雌二醇)测得值等。结果:治疗后,治疗组患者临床治疗的总有效率明显高于对照组(P<0.05);两组患者治疗后的Donders评分值、阴道健康评分值、阴道脱落细胞成熟指数值、E2及FSH值测得值均明显优于治疗前(P<0.05);治疗组患者的Donders评分值、阴道健康评分值、阴道脱落细胞成熟指数值、E2及FSH值测得值均优于对照组(P<0.05)。结论:采用甲硝唑栓与结合雌激素软膏联用治疗老年性阴道炎患者的临床疗效较好,明显改善了患者临床症状各项评分值与激素的分泌。
Objective: To evaluate the clinical effect of compound metronidazole suppository combined with estrogen ointment on senile vaginitis. Methods: 100 cases of senile vaginitis admitted from April 2014 to April 2016 in our hospital were divided into control group and treatment group according to random two-color ball grouping method, 50 cases in each group. Patients in control group received compound A Patients in the treatment group were treated with nitazoxan. The patients in the treatment group were treated with estrogen ointment in addition to the control group, and the total effective rate and clinical symptom scores of both groups were evaluated (Donders scoring system, vaginal health score and Assessment of vaginal exfoliation maturation index values) and hormone levels such as FSH (follicle stimulating hormone) and E2 (estradiol) measured values. Results: After treatment, the total effective rate of clinical treatment in treatment group was significantly higher than that in control group (P <0.05). The Donders score, vaginal health score, vaginal exfoliation maturation index, E2 and FSH (P <0.05). The Donders score, Vaginal health score, vaginal exfoliation maturation index, E2 and FSH values in the treatment group were significantly higher than those in the control group (P <0.05) <0.05). Conclusion: The clinical efficacy of metronidazole suppository combined with estrogen ointment in the treatment of senile vaginitis patients is better, which obviously improves the clinical symptom score and hormone secretion.