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目的探讨雷贝拉唑与奥美拉唑三联7日方案治疗幽门螺杆菌(Hp)相关性消化性溃疡患者的临床疗效。方法选取2012年12月至2014年12月辽宁省朝阳市第二医院收治的116例Hp相关性消化性溃疡患者,按随机数字表法将其分为甲组与乙组,各58例。甲组患者给予雷贝拉唑三联7日治疗方案,乙组患者采用奥美拉唑三联7日治疗方案,比较两组患者症状改善情况、Hp根除率、溃疡愈合情况以及不良反应发生情况。结果甲组患者治疗1 d后症状缓解率、Hp根除率均明显高于乙组,差异均有统计学意义(均P<0.05);甲组患者治疗后溃疡愈合率明显高于乙组,差异有统计学意义(P<0.05)。结论雷贝拉唑三联7日方案治疗Hp相关性消化性溃疡患者起效更快,其Hp根除效果与溃疡治愈程度均明显优于奥美拉唑治疗方案。
Objective To investigate the clinical efficacy of rabeprazole and omeprazole in combination with 7-day regimen in the treatment of patients with peptic ulcer associated with Helicobacter pylori (Hp). Methods A total of 116 patients with Hp-related peptic ulcer admitted to the Second Hospital of Chaoyang, Liaoning Province between December 2012 and December 2014 were randomly divided into group A and group B, 58 cases in each group. Patients in group A were given rabeprazole triple therapy on the 7th and group B in combination with omeprazole triple therapy for 7 days. The improvement of symptoms, Hp eradication rate, ulcer healing and adverse reactions were compared between the two groups. Results The symptom relief and Hp eradication rate in group A were significantly higher than those in group B after treatment for one day (all P <0.05). The healing rate of ulcer in group A was significantly higher than that in group B There was statistical significance (P <0.05). Conclusions Rabeprazole triple therapy on the 7th day in patients with Hp-related peptic ulcer onset faster onset of Hp eradication and ulcer cure were significantly better than omeprazole treatment options.