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表皮由排列紧密、间质很少的细胞组成,大部分是合成角质蛋白的角朊细胞,并最终由脱屑而脱落.这种脱落由基底细胞的持续增殖来补偿,这样,活表皮的生物学是由角化和生长调节所支配.这种调节有二个主要机制:第一个机制是表皮总是和其下的真皮接触,生长和角化是由通过基底膜的结缔组织因子控制的.根据第二个机制,信号是由成熟的角化细胞发出的,这些信号控制基底细胞的活性,可将它们阻滞在细胞分裂周期的不同阶段.使用表皮细胞培养作为活表皮模型
The epidermis is composed of closely arranged, interstitial cells, most of which are keratinocytes that synthesize keratin, and eventually shed by scaling, which is compensated by the continued proliferation of basal cells, so that living epidermal organisms Learning is dominated by keratinization and growth regulation.There are two main mechanisms for this regulation: the first is that the epidermis is always in contact with the underlying dermis, and the growth and keratosis are controlled by the connective tissue factor that passes through the basement membrane According to the second mechanism, signals are emitted by mature keratinocytes, which control the activity of basal cells and block them at different stages of the cell division cycle.Epithelial cell culture is used as a live epidermal model