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应用麻疹沪191株制备的疫苗原液与乙脑SA14-14-2株制备的疫苗原液混合制成二联疫苗，经试验其病毒滴度与其同批单价苗差异无显著意义（P＞0．2），联合苗与相应的标准抗血清均有高度的特异性，免疫小鼠后以乙脑JEP3株强毒攻击的保护效价与其单价乙脑苗差异亦无显著意义（P＞0．5）。表明两株病毒无干扰现象。试制3批二联苗，经全面检定，结果完全符合现行规程要求。其中病毒滴度麻疹苗为4．5LogCCID50／ml，乙脑苗为6．11～6．18LogPFU／ml，安全试验表明，二联合苗的弱毒力特性稳定。
Application of measles Shanghai 191 strains prepared vaccine and JE SA14-14-2 strains prepared vaccine mixture made of the two vaccines, the test virus titer difference with the same batch price of seedlings no significant difference (P> 0.2 ), The combined vaccine and the corresponding standard antiserum were highly specific. There was no significant difference in the protective titer against JEP3 virulent challenge in mice after immunization and the price difference of their single-price B seedlings (P> 0.5) . The two viruses showed no interference. Trials of two batches of two batches, the full test, the results in full compliance with the requirements of the current regulations. Among them, the virus titer of Measles vaccine was 4.5LogCCID50 / ml, while that of Japanese Encephalitis B vaccine was 6.11 ~ 6.18LogPFU / ml. Safety tests showed that the virulence characteristics of the two combined vaccine strains were stable.