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目的研究重楼总皂苷对人永生化角质形成细胞株(HaCaT细胞)增殖和分泌白介素8(IL-8)的影响。方法采用MTT法进行细胞增殖实验,采用ELISA法测定重楼总皂苷对HaCaT细胞分泌IL-8的情况。结果在所选浓度范围内(60μg/mL,90μg/mL,120μg/mL和150μg/mL),重楼总皂苷对HaCaT细胞的增殖有抑制作用;其中120μg/mL和150μg/mL浓度组重楼总皂苷可抑制HaCaT细胞自分泌IL-8,90μg/mL,120μg/mL和150μg/mL浓度组重楼总皂苷能抑制TNF-α(浓度为100U/mL),刺激HaCaT细胞分泌IL-8。结论重楼总皂苷能抑制HaCaT细胞增殖和IL-8的分泌。
Objective To study the effects of total saponins of Rhizoma Paridis on proliferation and secretion of interleukin-8 (IL-8) in human immortalized keratinocyte (HaCaT) cells. Methods Cell proliferation assay was performed by MTT method. The secretion of IL-8 by Haisong Tailou saponin was detected by ELISA. Results The total saponin of Rhizoma Paridis inhibited the proliferation of HaCaT cells in the selected concentration range (60μg / mL, 90μg / mL, 120μg / mL and 150μg / mL). The concentrations of 120μg / mL and 150μg / Total saponins could inhibit HaCaT cells from secrete IL-8,90μg / mL, 120μg / mL and 150μg / mL concentration of SSP can inhibit TNF-α (concentration of 100U / mL), stimulate HaCaT cells to secrete IL-8. Conclusion SSP can inhibit the proliferation of HaCaT cells and the secretion of IL-8.