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噻吗心安的全身副作用与药理作用直接有关的有:(1)支气管哮喘;(2)心功能不全;(3)缓脉;(4)房室传导阻滞;(5)周围循环障碍;(6)低血糖;(7)倦怠感等。与药理作用非直接关系的有:(1)头痛、忧郁、幻觉、恶梦;(2)恶心、呕吐、腹泻、便秘;(3)皮疹;(4)发热等。据Buskirk(1980)对美国国立药物所致眼部副作用登记局所登记的547例噻吗心安副作用的报告分析,50%与全身副作用有关。其中107例被认为是与β受体阻滞剂药理
Timolol systemic side effects and pharmacological effects are directly related to: (1) bronchial asthma; (2) cardiac insufficiency; (3) Bradyarrhythmia; (4) atrioventricular block; (5) the surrounding circulatory disorders; 6) hypoglycemia; (7) burnout and so on. And pharmacological effects are not directly related to: (1) headache, depression, hallucinations, nightmares; (2) nausea, vomiting, diarrhea, constipation; (3) rash; (4) fever and so on. According to a report by Buskirk (1980) on the report of 547 cases of timolol-related side effects registered by the National Registry of Ocular Side Effects of the United States Drugs, 50% were associated with systemic side effects. Of these, 107 were considered pharmacologically with beta-blockers