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目的:定量检测子痫前期、子痫患者及正常晚期妊娠孕妇血清超敏C-反应蛋白(h igh-sensitive C-reactiveprote in,hs-CRP)含量,揭示其与疾病发展的关系。方法:采用乳胶增强免疫比浊法定量检测52例子痫前期、18例子痫患者及20例正常妊娠晚期孕妇血清hs-CRP蛋白的含量。结果:hs-CRP含量子痫前期组及子痫组均显著高于正常妊娠组(P<0.01),子痫组显著高于子痫前期组(P<0.01),子痫前期重度组显著高于轻度组(P<0.01),有并发症组显著高于无并发症组(P<0.05)。结论:hs-CRP与妊娠期高血压疾病的发展密切相关,可以作为判断疾病轻重的指标,为早期检测及治疗提供有利的实验依据。
OBJECTIVE: To quantitatively detect the content of hs-CRP in preeclampsia, eclampsia and normal pregnant women with late pregnancy, and to reveal its relationship with disease development. Methods: Serum hs-CRP levels in 52 cases of preeclampsia, 18 cases of eclampsia and 20 cases of normal pregnant women were detected by latex enhanced immunoturbidimetry. Results: The levels of hs-CRP in preeclampsia group and eclampsia group were significantly higher than those in normal pregnancy group (P <0.01). The levels of hs-CRP in preeclampsia group were significantly higher than those in preeclampsia group (P <0.01) In the mild group (P <0.01), the complication group was significantly higher than the non-complication group (P <0.05). Conclusion: hs-CRP is closely related to the development of hypertensive disorder in pregnancy, which can be used as an index to judge the severity of disease. It provides a good experimental basis for early detection and treatment.