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目的对C反应蛋白(CRP)和基底节区脑出血早期神经功能恶化(END)的相互关系进行分析评价。方法选取2013年1月至2015年1月我院头CT确诊的基底节脑出血的60例患者。对临床资料进行回顾比较脑出血患者的基底资料及采用回归分析CRP水平与基底节区脑出血的相关性。结果 15例(25%)出现END,与未发生神经功能恶化的患者相比,END组CRP、高密度脂蛋白胆固醇(HDL)-C、血肿增大以出血破入脑室率都与正常组差异具有统计学意义(P<0.05)。经回归分析发现血肿面积、出血破脑室率、CRP等都和END呈正相关。结论 CRP对于临床预测基底节脑出血END存在重要的临床价值。
Objective To analyze and evaluate the relationship between C-reactive protein (CRP) and deterioration of early neurological deficits (END) in patients with basal ganglia hemorrhage. Methods Sixty patients with basal ganglia hemorrhage diagnosed by head CT in our hospital from January 2013 to January 2015 were selected. The clinical data were retrospectively compared with those of patients with cerebral hemorrhage and the correlation between CRP level and ICH was analyzed by regression analysis. Results END occurred in 15 cases (25%). Compared with patients without neurological deterioration, the levels of CRP, HDL-C and hematoma in the END group were significantly different from those in the normal group Statistically significant (P <0.05). The regression analysis showed that hematoma area, bleeding ventricular rate, CRP and END were positively correlated. Conclusion CRP has important clinical value in predicting basal ganglia cerebral hemorrhage.