The advancement and growth of nanotechnology lead to realizing new and novel multi-metallic nanos-tructures with well-defined sizes and morphology,resulting in an improvement in their performance in various catalytic applications.The trimetallic nanostructured materials are synthesized and designed in different architectures for energy conversion electrocatalysis.The as-synthesized trimetallic nanostruc-tures have found unique physiochemical properties due to the synergistic combination of the three dif-ferent metals in their structures.A vast array of approaches such as hydrothermal,solvothermal,seed-growth,galvanic replacement reaction,biological,and other methods are employed to synthesize the trimetallic nanostructures.Noteworthy,the trimetallic nanostructures showed better performance and durability in the electrocatalytic fuel cells.In the present review,we provide a comprehensive overview of the recent strategies employed for synthesizing trimetallic nanostructures and their energy-related applications.With a particular focus on hydrogen evolution,alcohol oxidations,oxygen evolution,and others,we highlight the latest achievements in the field.