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本文采用原子吸收分光光度法对12例HLD患者、10例杂合子、16例对照者的离体培养皮肤成纤维细胞内锌的含量进行了测定。结果显示,三者之间细胞内锌的含量无显著差异(P均>0.5)。这一结果提示,HLD患者体内锌代谢的改变可能是一种继发性的改变,而不是本病原发性的代谢障碍。这对研究锌在HLD发病机制中的作用以及指导锌剂在治疗本病上的应用均有重要意义。
In this paper, the content of zinc in cultured skin fibroblasts from 12 HLD patients, 10 heterozygotes and 16 controls were determined by atomic absorption spectrophotometry. The results showed that there was no significant difference in intracellular zinc content between the three groups (P> 0.5). This result suggests that changes in zinc metabolism in HLD patients may be a secondary change, rather than the primary metabolic disorder of the disease. This study of the role of zinc in the pathogenesis of HLD and guide the application of zinc in the treatment of the disease are of great significance.