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测定了罗红霉素、ａｚｉｔｈｒｏｍｙｃｉｎ、头孢西丁、托舒沙星对６０株厌氧菌的体外抗菌活性，并同甲硝唑比较，发现托舒沙星对厌氧菌的体外抗菌活性最好，ＭＩＣ_（５０）和ＭＩＣ_（９０）为０．１２５和２ｍｇ／Ｌ优于甲硝唑（０．２５和１６ｍｇ／Ｌ）；罗红霉素（０．５、１６ｍｇ／Ｌ）与甲硝唑相似，ａｚｉｔｈｒｏｍｙｃｉｎ、头孢西丁的体外抗菌活性比甲硝唑略差，ＭＩＣ_（５０）和ＭＩＣ_（９０）分别为４和３２、２和３２ｍｇ／Ｌ，它们对脆弱拟杆菌的体外抗菌活性优于对其它拟杆菌的体外抗菌活性，对短真杆菌、变形链球菌、普氏消化链球菌等也具有较好的体外抗菌活性。
The antibacterial activities of roxithromycin, azithromycin, cefoxitin and tosufloxacin on 60 strains of anaerobic bacteria were determined in vitro and compared with metronidazole. The results showed that in vitro antibacterial activity of tosufloxacin against anaerobic bacteria was the best , MIC 50 and MIC 90 were 0.125 and 2 mg / L better than metronidazole (0.25 and 16 mg / L), while roxithromycin (0.5 and 16 mg / L) Similarly, the antibacterial activity of azithromycin and cefoxitin was slightly worse than that of metronidazole. MIC 50 and MIC 90 were 4 and 32, 2 and 32 mg / L, respectively, which showed superior in vitro antibacterial activity against Bacteroides fragilis In vitro antibacterial activity of other Bacteroidetes against Bacillus licheniformis, Streptococcus mutans, Peptostreptococcus, also has good antibacterial activity in vitro.