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研究表明,干扰素的抗肿瘤作用主要是通过对肿瘤细胞的生长抑制调节而不是由于其免疫调节作用。应用α-干扰素(IFN-α)治疗毛细胞白血病,有效率可达70％-90％,治疗数月后,病人外周血细胞计数正常,骨髓象改善。IFN-α治疗多发性骨髓瘤疗效不如常规化疗好。意大利的一组研究证明,IFN-α作为化疗的辅助治疗可明显延长化疗药物的作用时间,提高存活率。IFN-α治疗实体瘤,如恶性内分泌性胰腺肿瘤,与AIDS有关的Kaposi’s肉瘤和少数肾细胞瘤及黑色素瘤病人有一定疗效。IFN-α局部应用治疗膀胱、卵巢肿瘤和黑色素瘤也有效。
Studies have shown that the anti-tumor effects of interferon are mainly regulated by the growth inhibition of tumor cells rather than their immunomodulatory effects. The use of alpha-interferon (IFN-alpha) in the treatment of hairy cell leukemia, the effective rate of up to 70% -90%, after several months of treatment, the patient’s peripheral blood cell count is normal, bone marrow image improved. The efficacy of IFN-α in the treatment of multiple myeloma is not as good as conventional chemotherapy. A group of studies in Italy showed that IFN-α as an adjunct to chemotherapy can significantly prolong the time of action of chemotherapeutic agents and improve survival. IFN-α treatment of solid tumors, such as malignant endocrine pancreatic tumors, AIDS-related Kaposi’s sarcoma and a small number of renal cell tumors and melanoma patients have a certain effect. Topical application of IFN-α is also effective for the treatment of bladder, ovarian tumors and melanoma.