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5. Synthesis and Biological Evaluation of Novel 1,5-Diarylpyrazole-3-carboxamide Compounds as Inhibitor

Synthesis and Biological Evaluation of Novel 1,5-Diarylpyrazole-3-carboxamide Compounds as Inhibitor

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：rona

【摘 要】

：

Ten new 1, 5-diarylpyrazole-3-carboxamide compounds were synthesized and their structures were identified by 1H-NMR and FAB-MS. The primary biological tests sho

【作 者】

：

Xian Ping DAI Xing Zhou LI Zhi 

【机 构】

：

School of Pharmaceutical Engineering,Beijing Institute of Pharmacology & Toxicology

【出 处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

1 5-Diarylpyrazole-3-carboxamide synthesis inhibitors ALK5 

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论文部分内容阅读

Ten new 1, 5-diarylpyrazole-3-carboxamide compounds were synthesized and their structures were identified by 1H-NMR and FAB-MS. The primary biological tests showed that compound 4j exhibited some ALK5 inhibitory activity at concentration of 1 μmol/L.

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