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目的 :探讨生化调节 MFP方案 (MTX、5 - Fu、DDP)治疗晚期胃癌的疗效与副作用。方法 :1998年 6月— 2 0 0 0年 6月应用 MFP方案治疗晚期胃癌 42例。结果 :全组总有效率 (CR+PR) 4 7.6 % ,对初次化疗患者有效率 6 6 .7% ,对以往接受过化疗者有效率 37.0 4% ,对以往接受过 5 - Fu治疗者有效率 36 .8%。统计学分析显示 ,MFP方案对初次化疗者的有效率显著高于以往接受过化疗者。无明显毒副作用。结论 :对晚期胃癌具有良好的治疗效果 ,值得临床推广应用。
Objective :To investigate the efficacy and side effects of biochemically modified MFP regimen (MTX,5-Fu,DDP) in the treatment of advanced gastric cancer. Methods: From June 1998 to June 2000, 42 patients with advanced gastric cancer were treated with MFP regimen. Results: The total effective rate of the whole group (CR+PR) was 4 7.6 %, the effective rate was 66.7% for the patients with primary chemotherapy, and the effective rate was 37.0 4% for those who had received chemotherapy before. For those who had received 5 - Fu treatment in the past 36.8% efficiency. Statistical analysis showed that the efficiency of the MFP regimen for primary chemotherapy was significantly higher than that of previous chemotherapy. No obvious side effects. Conclusion : It has good therapeutic effect on advanced gastric cancer and is worthy of clinical application.