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目的:评价痛经宝优化方的镇痛、抗炎效应,分析其起镇痛、抗炎作用的药效组分。方法:将动物分为模型组、痛经宝颗粒组、痛经宝优化方不同组分组,采用缩宫素致小鼠痛经模型并结合模型小鼠血钙含量,子宫MDA,NO,PGE2的含量测定,评价痛经宝优化方不同组分的镇痛、抗炎效应及产生的影响。结果:痛经宝优化方各组分可以延长痛经小鼠的痛经潜伏期,减少小鼠平均扭体次数,提高扭体抑制率,降低痛经模型小鼠的血钙含量及子宫中MDA,PGE2的含量,提高子宫中NO的含量。结论:痛经宝优化方各组分均具有镇痛、抗炎作用,不同组分在治疗痛经的多个环节具有协同作用。
OBJECTIVE: To evaluate the analgesic and anti-inflammatory effects of optimized prescription of dysmenorrhea, analgesic and anti-inflammatory effects. Methods: The animals were divided into three groups: model group, Tongjingbao granule group and Tongjingbao optimized group. Using oxytocin-induced dysmenorrhea model and combined with the content of serum calcium, uterine MDA, NO and PGE2 in model mice, To evaluate the analgesic and anti-inflammatory effects and the effects of different components of Optimizing Decoction of Pain. Results: The components of Optimizing Decoction of Pain Decoction can prolong the latency of dysmenorrhoea in mice with dysmenorrhoea, reduce the average number of writhing in mice, increase the inhibition rate of writhing, decrease the content of calcium in mice with dysmenorrhoea and the contents of MDA and PGE2 in uterus, Uterine increase the content of NO. Conclusion: The components of optimized prescription of dysmenorrhoea have analgesic and anti-inflammatory effects and synergistic effects of different components in treating dysmenorrhea.