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目的采用动物实验模型观察急性坏死性胰腺炎合并内脏损伤时门静脉血中血栓素（Thomboxane，TX）和前列环素（prostagtandin，PG）水平变化。方法用牛黄胆酸钠复制大鼠急性坏死性胰腺炎模型，放射免疫分析法测定血浆中TYB2和6－keto—PGF1α的含量来反映TXA2和PGI2的水平，并设对照组（假手术组）进行对照分析。结果实验组大鼠血浆中TYA2和PGI2水平较对照组高（P＜0．05），实验组大鼠腹腔静脉血TXA2和PGI2水平比门静止高（P＜0．05），PGVI2／TXA2比值下降资料处理采用t检验。结论TXA2PGI2是参与急性坏死性胰腺炎合并内脏损伤病理机制的重要因素之一。
Objective To investigate the changes of thromboxane (TX) and prostaglandin (PG) levels in portal venous blood of patients with acute necrotizing pancreatitis complicated with visceral injuries by animal model. Methods Rat models of acute necrotizing pancreatitis were induced by sodium taurocholate, and the contents of TYB2 and 6-keto-PGF1α in plasma were measured by radioimmunoassay to reflect the levels of TXA2 and PGI2. The control group (sham operation group) Control analysis. Results The levels of TXA2 and PGI2 in the experimental group were higher than those in the control group (P <0.05). The levels of TXA2 and PGI2 in the experimental group were significantly higher than those in the portal vein (P <0.05), and the ratio of PGVI2 / TXA2 Decline data processing using t test. Conclusion TXA2PGI2 is one of the important factors involved in the pathological mechanism of visceral injury in acute necrotizing pancreatitis.