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生长抑素(somatostatin)是作用最广泛的一种下丘脑神经激素,除对垂体生长激素(GH)分泌细胞有抑制作用外,还可抑制LH、FSH、TSH、PRL、ACTH的分泌,主要存在于下丘脑和胃肠道,其中70％分布于胃肠道,对胃肠道的内分泌和外分泌功能、动力和血流都有抑制作用,是作为一种内分泌、旁分泌、自分泌和神经分泌的因子而起作用。施他宁(stilamin)是人工合成的环状十四氨墓酸肽,与天然生长抑素在化学结构和作用方面完全相同。近年广泛应用于消化道出血(特别是食管静脉曲张破裂出血)的治疗,本文总结经其它药物治疗无效的严重消化道出血54例,用施他宁治疗后的转归,并着重分析施他宁对心脏的影响。
Somatostatin is one of the most widely used hypothalamic neurohormones, which can inhibit the secretion of LH, FSH, TSH, PRL and ACTH in addition to inhibiting the secretion of pituitary growth hormone (GH) In the hypothalamus and gastrointestinal tract, of which 70% distributed in the gastrointestinal tract, the gastrointestinal endocrine and exocrine function, motility and blood flow are inhibited, as an endocrine, paracrine, autocrine and neuroendocrine Of the factors and work. Stilamin, a synthetic cyclic cyclic amide peptide, is identical in chemical structure and action to natural somatostatin. In recent years, widely used in the treatment of gastrointestinal bleeding (esophageal variceal bleeding in particular), this article summarizes the 54 cases of severe gastrointestinal bleeding ineffective by other drugs, with metastasizing after treatment outcome, and focused on the analysis of Strychnine Impact on the heart.