To collect neuronal activity data from awake, freely behaving animals, we developed miniature telemetry recording system. The integrated system consists of four major components: l) Microelectrodes and micro-driver assembly, 2) analog front end (AFE), 3) programmable system on chip (PSoC), and 4) ra- dio transceiver and the LabVIEW were used as a platform for the graphic user interface. The result showed the system was able to record and analyze neuronal recordings in freely moving animals and lasted continuously for a time period of a week or more. This is very useful for the study of the interdisciplinary research of neu- roscience and information engineering techniques. The circuits and architecture of the devices can be adapted for neurobiology and research with other small animals.