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硝苯吡啶(Nifedipine)是一种抑制Ca~(2+)跨膜内流入平滑肌细胞的新型钙拮抗剂。已用于心绞痛治疗,尤其是它与β受体阻断剂合用时,能明显降低心绞痛的严重程度。其作用可能由Nifedipine降低外周动脉阻力及收缩压、减轻冠状动脉痉挛及增加心肌血流量所致。血小板在冠状动脉硬化性心脏病(CHD)进展中起一定作用。附壁血栓附着在动脉粥样硬化的管壁上,使其斑块增厚;血小板释放血栓素,后者可引起冠状动脉收缩,加重心肌缺血;聚集的血小板还能阻塞小血管,在猝死后的冠状动脉常见聚集的血小板。
Nifedipine is a novel calcium antagonist that inhibits the influx of Ca ~ (2+) into smooth muscle cells. Has been used for angina treatment, especially when it is combined with β-blockers, can significantly reduce the severity of angina pectoris. Its role may be reduced by Nifedipine peripheral arterial resistance and systolic blood pressure, reduce coronary artery spasm and increase myocardial blood flow caused. Platelets play a role in the progression of coronary heart disease (CHD). Mural clot attached to the wall of atherosclerotic plaque, thickened plaque; platelets release thromboxane, which can cause coronary artery contraction, aggravating myocardial ischemia; aggregated platelets also block small blood vessels in the sudden death Coronary artery after the common aggregation of platelets.