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目的评价术前术后服用非那雄胺对经尿道前列腺电切除术(transurethral resection of prostate,TURP)术中术后出血的影响。方法176例良性前列腺增生症(benign prostatic hyperplasia,BPH)患者,对于术前7 d及术后30 d服用非那雄胺5 mg的60例患者纳为5 mg组,服用10 mg的60例患者纳为10 mg组,未服用非那雄胺的56例患者纳为未服药组,比较三组TURP术中、术后失血量及术后镜下血尿转阴时间。结果176例TURP术均获得成功。与未服药组比较,服药组的术中冲洗液量、术中失血量、平均切除1 g前列腺组织失血量、术后冲洗时间、术后冲洗液量、术后失血量均显著降低,差异有统计学意义(P<0.05),但是5 mg组与10 mg组差异无统计学意义;术后镜下血尿转阴时间,服药组明显缩短且10 mg组差异有统计学意义(P<0.05)。结论术前应用非那雄胺7 d能够有效减少TURP术中术后失血量;术后应用非那雄胺10 mg/d的能够明显缩短TURP术后镜下血尿阴转时间,减少术后出血。
Objective To evaluate the effect of preoperative and postoperative finasteride on postoperative bleeding after transurethral resection of prostate (TURP). Methods A total of 176 patients with benign prostatic hyperplasia (BPH) were enrolled in the 5 mg group for 60 patients taking finasteride 5 mg at 7 days and 30 days after operation. Sixty patients taking 10 mg of benign prostatic hyperplasia (BPH) Satisfied for the 10 mg group, did not take finasteride 56 patients were not taken as non-medication group, compared three groups of TURP surgery, postoperative blood loss and postoperative microscopic hematuria negative time. Results 176 cases of TURP were successful. Compared with the non-medication group, the volume of intraoperative washing fluid, intraoperative blood loss, average removal of 1 g of prostate tissue blood loss, postoperative rinse time, postoperative rinse volume, postoperative blood loss were significantly decreased, the difference was (P <0.05), but there was no significant difference between the 5 mg and 10 mg groups. The time of microscopic hematuria and gastrectomy was shorter and the difference was statistically significant (P <0.05) . Conclusion Preoperative application of finasteride for 7 days can effectively reduce postoperative blood loss after TURP; postoperative application of finasteride 10 mg / d can obviously shorten the time of microscopic hematuria after TURP operation and reduce postoperative bleeding .