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目的通过对砷化物、铅、苯、聚氯乙烯单体氯乙烯暴露工人外周血淋巴细胞微核的研究,探讨4种工业毒物的细胞遗传学效应及在职业病诊断上的意义。方法砷化物、铅、苯、聚氯乙烯单体氯乙烯工业毒物的暴露工人作为接触组,不接触任何毒物的健康人群作为对照组,通过常规培养法进行外周血淋巴细胞微核率测定。结果铅、苯暴露工人外周血淋巴细胞微核率高于对照组(P<0.05),砷化物、聚氯乙烯单体氯乙烯暴露工人外周血淋巴细胞微核率与对照组比较,差异无统计学意义(P>0.05)。结论铅、苯有细胞遗传学效应,砷化物、聚氯乙烯单体氯乙烯在接触水平较低情况下没有细胞遗传学效应。
OBJECTIVE: To study the cytogenetic effects of four industrial toxicants and their significance in the diagnosis of occupational diseases by studying the micronuclei of peripheral blood lymphocytes exposed to arsenic, lead, benzene and polyvinyl chloride monomer vinyl chloride monomer. Methods Workers exposed to arsenic, lead, benzene and polyvinyl chloride (PVC) industrial toxicants were used as the control group in the exposure group and healthy people without any toxicants. The micronuclei of peripheral blood lymphocytes were determined by routine culture method. Results The micronucleus rate of peripheral blood lymphocytes in workers exposed to lead and benzene was higher than that in the control group (P <0.05). There was no significant difference in the micronucleus rate between peripheral blood lymphocytes exposed by arsenic chloride and polyvinyl chloride monomer in comparison with the control group Significance (P> 0.05). Conclusions Lead and benzene have cytogenetic effect. There is no cytogenetic effect of arsenic and polyvinyl chloride monomer vinyl chloride in the low contact level.