对氨基水杨酸钠(PAS-Na)作为抗结核药应用已有多年,虽然毒性较小,但连续服用量较大,且本品稳定性差,PAS-Na的降解反应是先脱羧,后氧化、聚合,因此产生不同程度的颜色。为了确保用药安全与有效,本文拟对其稳定性及影响色泽变化的各种因素进行探讨。 Sodium p-aminosalicylate (PAS-Na) has been used as an anti-TB drug for many years. Although its toxicity is relatively small, it is taken continuously for a long time and its stability is poor. The degradation reaction of PAS-Na is decarboxylation and post-oxidation , Polymerization, resulting in different degrees of color. In order to ensure drug safety and effectiveness, this paper intends to discuss its stability and the factors that affect the color change.