目的　本研究对早期单次静脉注射沙丁胺醇治疗急性重症哮喘的有效性再次进行分析。方法　采用随机双盲、安慰剂对照方法对 84例重症哮喘患儿进行研究。在临床评估后 ,重症哮喘患儿吸入大量沙丁胺醇并静脉置管 ,其他治疗包括静脉注射甲基强的松龙 (1mg/kg)、氧疗(若SaO2 为 93% ,则面罩吸氧 6L/min)。患儿随机分为静脉注射沙丁胺醇 (15mg/kg)或盐水两组 ,每小时进行 1次临床评估 ,共 2h。所有患儿收住院按治疗常规吸入沙丁胺醇并继续监测 2～ 2 4h。结果　沙丁胺醇组 (n =5 0 )较盐水组临床改善早 ,且较早停止吸氧和吸入沙丁胺醇。静注沙丁胺醇组较对照组提前 3 7h离开急诊室或提前 9 7h出院。两组均未发现显著副作用。结论　急性重症哮喘患儿早期 (于入急诊室 10min内 )静注沙丁胺醇 15mg/kg ,可缩短哮喘发作时间和减少持续吸入沙丁胺醇的用量 Purpose This study again analyzed the effectiveness of early single intravenous salbutamol in the treatment of acute severe asthma. Methods A randomized, double-blind, placebo-controlled trial was conducted in 84 children with severe asthma. After clinical assessment, patients with severe asthma inhaled large amounts of albuterol and intravenous catheterization, other treatments include intravenous methylprednisolone (1mg / kg), oxygen therapy (if SaO2 is 93%, the mask oxygen 6L / min ). Children were randomly divided into intravenous salbutamol (15mg / kg) or saline two groups, once a hour for clinical evaluation, a total of 2h. All children admitted to hospital according to conventional inhalation of salbutamol and continue to monitor 2 ~ 2 4h. Results The salbutamol group (n = 50) had earlier clinical improvement than saline group, and oxygen inhalation and inhalation of albuterol were stopped earlier. The intravenous albuterol group than the control group to leave the emergency room 37h ahead of schedule or discharge 9h earlier. No significant side effects were found in both groups. Conclusions Early intravenous salbutamol 15 mg / kg in acute severe asthma children (within 10 minutes into the emergency department) can shorten the time of asthma attack and reduce the amount of salbutamol inhaled