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目的 :研究MN/CA9蛋白的表达和肾细胞癌的关系 ,探讨MN/CA9蛋白在肾细胞癌诊断研究中的应用。方法 :应用免疫组化和免疫印迹的方法 ,对正常肾组织、良性肾损害和肾细胞癌组织的MN/CA9蛋白的表达进行了分析。结果 :正常人肾组织和良性肾损害均为MN/CA9阴性 ,而在 30例肾癌中却有 2 8例为MN/CA9阳性 ,尤其是 2 6例富糖原型RCC均呈现MN/CA9强阳性。结论 :MN/CA9蛋白可作为肾细胞癌尤其是富糖原型肾细胞癌的一种标志物
Objective: To investigate the relationship between MN / CA9 protein expression and renal cell carcinoma and to explore the application of MN / CA9 protein in the diagnosis of renal cell carcinoma. Methods: Immunohistochemistry and Western blotting were used to analyze the expression of MN / CA9 protein in normal renal tissues, benign renal lesions and renal cell carcinoma tissues. Results: Normal renal tissue and benign renal lesions were negative for MN / CA9, while in 30 cases of renal cell carcinoma, 28 cases were MN / CA9 positive, especially 26 cases of glycated RCC showed MN / CA9 strong Positive. Conclusion: MN / CA9 protein can be used as a marker of renal cell carcinoma, especially glycogen-rich renal cell carcinoma