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目的:了解我院抗微生物药不良反应的情况,为临床合理用药提供参考。方法:回顾性分析我院2004～2008年的抗微生物药物不良反应报告。结果:659例药品不良反应(ADR)报告中,以头孢菌素类药发生例数最多(35.51%),其次为喹诺酮类(25.34%)和青霉素类(19.73%);ADR的给药途径主要是静脉给药(88.01%);涉及的系统器官主要为皮肤及附件(53.87%)。结论:抗微生物药不良反应的发生与药物类型、给药途径、用药频率等密切相关,应提高医护人员对ADR的警惕性和不良反应监测水平,加强对抗微生物药物不良反应的监测,预防和及时报告ADR,以保证用药安全性和合理性。
Objective: To understand the adverse reactions of antimicrobial agents in our hospital and provide references for clinical rational drug use. Methods: A retrospective analysis of our hospital from 2004 to 2008 antimicrobial adverse drug reactions report. Results: The highest incidence of cephalosporins (35.51%) was reported in 659 ADRs, followed by quinolones (25.34%) and penicillins (19.73%). The main routes of ADR administration were mainly Is administered intravenously (88.01%); the main systemic organs involved are skin and appendages (53.87%). Conclusions: The occurrence of adverse reactions of antimicrobial agents is closely related to the type of drug, the route of administration and the frequency of medication. The vigilance of ADRs and the monitoring of adverse reactions should be enhanced, and the monitoring, prevention and timely response to adverse reactions of microbiological drugs should be strengthened Report ADR to ensure medication safety and rationality.