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目的探讨CEA、CA125在良、恶性胸腔积液鉴别诊断中的价值。方法对46例恶性胸腔积液、44例良性胸腔积液患者于治疗前分别抽取血清及第1次胸腔积液标本进行CA125、CEA测定。结果恶性胸腔积液组血清和胸腔积液CA125、CEA测定值高于良性胸腔积液组(P<0.01)。在胸腔积液中,CA125假阴性56.5%(26/46),假阳性86.4%(38/44);CEA假阴性67.4%(31/46),假阳性81.8%(36/44);CEA和CA125联合检测假阴性69.6%,假阳性90.9%。结论胸腔积液CA125和CEA联合检测有利于良恶性胸腔积液的鉴别,且比血清中更具有临床价值。
Objective To investigate the value of CEA and CA125 in the differential diagnosis of benign and malignant pleural effusion. Methods 46 patients with malignant pleural effusion and 44 patients with benign pleural effusion before treatment were drawn serum and first pleural effusion specimens for CA125, CEA determination. Results Serum and pleural effusion CA125 and CEA in malignant pleural effusion group were higher than those in benign pleural effusion group (P <0.01). In pleural effusion, CA125 false negative 56.5% (26/46), false positive 86.4% (38/44); CEA false negative 67.4% (31/46), false positive 81.8% (36/44); CEA and CA125 combined detection of false negative 69.6%, false positive 90.9%. Conclusions The combined detection of pleural effusion CA125 and CEA is good for the differential diagnosis of benign and malignant pleural effusions and has more clinical value than serum.