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目的了解常住和流动人口孕妇产前筛查唐氏综合征(DS)、18三体综合症和开放性神经管缺陷(ONTD)胎儿的应用情况。方法了解常住和流动人口孕妇产前筛查唐氏综合征(DS)、18三体综合症和开放性神经管缺陷(ONTD)胎儿的应用情况。结果产前筛查40 214例孕妇,共筛查出高危孕妇2 050例,总阳性率为5.1%,其中DS高风险1 315例、ONTD高风险129例、18三体综合症高风险41例和年龄≥35岁的565例,其高风险检出率分别为3.3%、0.3%、0.1%和1.4%。常住人口和流动人口的产前筛查率、筛查阳性高风险率分别为93.7%、5.3%和52.1%、4.2%,差异均有统计学意义(χ2分别为6420.748和9.325,P<0.01),羊水穿刺率和无创DNA送检率分别为48.2%、1.0%和40.7%、0.7%,差异均无统计学意义。结论流动人口孕妇的产前筛查率和羊水穿刺率偏低,年龄高风险率偏高,在做好常住人口产前筛查工作同时,应进一步加强对流动人口产前筛查工作,以减少出生缺陷提高全民素质。
Objective To investigate the application of prenatal screening for Down’s syndrome (DS), Trisomy 18, and open neural tube defects (ONTD) fetuses in pregnant and migrant women. Methods To understand the application of fetal prenatal screening for Down’s syndrome (DS), Trisomy 18 and open neural tube defects (ONTD) in pregnant and mobile population of pregnant and floating population. Results A total of 4014 pregnant women were enrolled in prenatal screening. A total of 2050 high-risk pregnant women were screened out, with a total positive rate of 5.1%. Among them, 1315 were high risk of DS, 129 were high risk of ONTD, 41 were high risk of trisomy 18 And 565 patients aged 35 years or older, the high-risk detection rates were 3.3%, 0.3%, 0.1% and 1.4% respectively. The prenatal screening rate and screening high risk rate of resident population and floating population were 93.7%, 5.3% and 52.1%, 4.2%, respectively, with significant differences (χ2 = 6420.748 and 9.325, P <0.01) , Amniocentesis rate and non-invasive DNA delivery rate were 48.2%, 1.0% and 40.7%, 0.7%, the difference was not statistically significant. Conclusion Prenatal screening rate and amniocentesis rate of pregnant women in floating population is low and high age risk rate is high. While prenatal screening of resident population should be carried out, prenatal screening should be further strengthened to reduce Birth defects improve the quality of the general public.