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目的探讨他巴唑引起的急性粒细胞缺乏症的有效治疗措施。方法回顾性分析5例他巴唑引起的急性粒细胞缺乏症患者临床资料。结果4例在服药后2个月内发生粒缺,1例在2年后发生。临床表现均为突发高热、咽痛。所有患者停用他巴唑,选用广谱抗生素、粒细胞集落刺激因子(G-CSF)、糖皮质激素等综合治疗,4例治愈,1例死亡。结论他巴唑治疗过程中应高度警惕并发急性粒细胞缺乏症之可能。早期应用广谱抗生素抗感染,迅速提升白细胞,合理应用糖皮质激素,积极治疗甲亢等综合治疗措施具有较好疗效。
Objective To investigate the effective treatment of methimazole-induced acute agranulocytosis. Methods A retrospective analysis of 5 cases of methimazole-induced acute neutropenia in patients with clinical data. Results 4 cases occurred grain defects within 2 months after taking medicine, and 1 case occurred after 2 years. Clinical manifestations are sudden high fever, sore throat. All patients stopped methimazole, the choice of broad-spectrum antibiotics, granulocyte colony stimulating factor (G-CSF), glucocorticoid and other comprehensive treatment, 4 patients were cured, 1 patient died. Conclusion Methimazole treatment should be highly vigilant against the possibility of acute agranulocytosis. Early application of broad-spectrum antibiotics anti-infection, rapid increase of white blood cells, rational use of glucocorticoids, active treatment of hyperthyroidism and other comprehensive treatment measures have a good effect.