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研究表明：氧化ＬＤＬ（Ｏｘ－ＬＤＬ）可抑制ＬＰＳ诱导的巨噬细胞ＮＯ释放，而正常ＬＤＬ和乙酰化ＬＤＬ则无抑制作用。用谷胱甘肽过氧化物酶模拟物ｅｂｓｅｌｅｎ清除Ｏｘ－ＬＤＬ上的脂氢过氧化物对其抑制作用没有影响。Ｏｘ－ＬＤＬ的蛋白组分对ＮＯ释放也没有影响，而脂质组分则有抑制作用。ＬＤＬ脂质的主要成分亚油酸和卵磷脂无论单独还是共同氧化后对ＮＯ释放都没有影响，而亚油酸和胆固醇一起氧化后则对ＮＯ的释放有很强的抑制作用，胆固醇单独氧化后也有一定的抑制作用，提示氧化胆固醇可能是Ｏｘ－ＬＤＬ对ＮＯ释放起抑制作用的主要因素。
Studies have shown that oxidized LDL (Ox-LDL) can inhibit LPS-induced macrophage NO release, while normal LDL and acetylated LDL have no inhibitory effect. Cleavage of lipid hydroperoxides on Ox-LDL with glutathione peroxidase mimic ebselen had no effect on its inhibition. The protein component of Ox-LDL has no effect on NO release, while the lipid component has an inhibitory effect. The main component of LDL lipids linoleic acid and lecithin, whether alone or co-oxidized NO release has no effect, while linoleic acid and cholesterol oxidation after the release of NO have a strong inhibitory effect, after the oxidation of cholesterol alone Also have some inhibition, suggesting that oxidized cholesterol may Ox-LDL NO release inhibition of the main factors.