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目的:探索威斯康星卡片分类测验测试各指标中更稳定、更精确的指标(内表型)。方法:在重庆市主城区募集6-16岁的双生子。签写知情同意书后,用威斯康星卡片分类测验对59对6-16岁的双生子测试(同卵双生28对,异卵双生31对),比较双生子两个体之间的六个常用指标(正确数、错误数、持续错误数、非持续错误数、总分类数、完成第一个分类所需个数)得分的相关系数,采取双生子的颊黏膜标本以提取DNA并进行卵型鉴定。结果:MZ组和DZ组的年龄、性别、受教育年限具有可比性(P>0.05),MZ组的持续错误数指标在双生子对个体之间的相关系数有显著相关(r=0.65,P=0.001),其余五个指标和DZ组的六个指标在双生子对个体之间的得分无显著性相关(P>0.05)。结论:在威斯康星卡片分类测验常用的六个指标中,持续错误数受遗传的影响更大,作为内表型指标可能优于威斯康星卡片分类测验中的其他指标。
OBJECTIVE: To explore more stable and accurate indices (endophenotypes) among the various indicators of the Wisconsin Card Classification Test. Methods: In the main city of Chongqing to raise twins 6-16 years old. After writing the informed consent form, twins test was performed on 59 pairs of 6-16 year olds (28 pairs of identical twins and 31 pairs of fraternal twins) using the Wisconsin Card Classification Test and six commonly used indicators between the twins The number of false positives, the number of false positives, the number of persistent errors, the number of non-persistent errors, the total number of categories, the number of first classifications needed to complete the score) correlation coefficients were taken from twins to buccal mucosa specimens for DNA extraction and egg identification. Results: The age, gender and education years of MZ group and DZ group were comparable (P> 0.05). The continuous error index of MZ group was significantly correlated with the correlation coefficient between twins (r = 0.65, P = 0.001). There was no significant correlation between the other five indicators and the six indicators in the DZ group (P> 0.05). CONCLUSIONS: Of the six commonly used indicators of the Wisconsin card triage test, the number of persistent errors is more genetically influenced and may be superior to the other indicators in the Wisconsin Card Sorting Test as an endogenous indicator.