肝癌(以下简称PHC)为我国常见多发肿瘤,近年统计国内占消化道肿瘤死亡率第三位。自1973年Nishika提出了PHC与HBV感染有密切关系,此后,各国学者对此问题做了大量工作,如流行病学调查、血清及组织免疫化学研究、细胞生物学肝癌细胞株的建立,特别是分子生物学和遗传工程技术的研究 Liver cancer (hereafter abbreviated as PHC) is a common multiple tumor in China. In recent years, it has accounted for the third highest mortality rate of digestive cancer in China. Since 1973, Nishika proposed that PHC has a close relationship with HBV infection. Since then, scholars from various countries have done a lot of work on this issue, such as epidemiological surveys, serum and tissue immunochemistry studies, and the establishment of cell biology liver cancer cell lines, especially Research on Molecular Biology and Genetic Engineering Technology