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目的:探讨不同途径应用卡孕栓预防产后出血的效果。方法:将正常单胎头位阴道分娩孕妇分为卡孕栓1组、卡孕栓2组和对照组,卡孕栓1组480例,胎儿娩出后予卡孕栓1 mg直肠用药,卡孕栓2组胎头娩出后予卡孕栓1 mg舌下含服,对照组胎儿娩出后予催产素20 IU肌内注射,观察产后2 h、24 h出血量及产后出血发生率。结果:卡孕栓1组、卡孕栓2组产后2 h、24 h出血量及产后出血发生率比较差异无统计学意义(P>0.05),卡孕栓组与对照组比较,产后2 h、24 h出血量及产后出血发生率比较差异均有统计学意义(P<0.05)。结论:卡孕栓舌下含服或直肠给药预防产后出血效果显著,舌下含服因使用方便,更适合临床推广。
Objective: To explore the effect of different routes of application of carbamazepine to prevent postpartum hemorrhage. Methods: The pregnant women with normal single head vaginal delivery were divided into 1 group of carbamazepine, 2 groups of carbamazepine and control group, 480 cases of carbamazepine group 1, 1 mg of carbamazepine rectal administration after delivery, The rats in the control group received 20 IU intramuscular injection of oxytocin after intrauterine injection of 1 mg carbamazepine, and the amount of hemorrhage and the incidence of postpartum hemorrhage at 2 h and 24 h postpartum were observed. Results: There was no significant difference in the amount of hemorrhage and the incidence of postpartum hemorrhage between the two groups (P <0.05). The incidence of hemorrhage after 2 and 24 h was significantly higher than that of the control group , 24 h bleeding and the incidence of postpartum hemorrhage were significantly different (P <0.05). Conclusion: The effect of subconjunctival subconjunctival buccal or rectal administration on preventing postpartum hemorrhage is obvious. The sublingual administration is more suitable for clinical promotion due to its convenient use.