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目的:探讨PRL-3和VEGF在结肠癌组织中的表达及其临床意义。方法:用免疫组织化学技术检测50例结肠癌组织及相应癌旁组织中PRL-3和VEGF的表达,并分析其与患者临床病理变量的关系及其对预后的影响。结果:PRL-3和VEGF在结肠癌组织表达上调明显高于癌旁组织,有统计学意义。PRL-3和VEGF的阳性表达率与肿瘤分化程度、淋巴结转移、及TNM分期有关。而与年龄、性别、肿瘤大小无关(P>0.05)。PRL-3和VEGF表达上调者的中位生存时间明显短于低表达者。PRL-3和VEGF表达有显著相关性。结论:PRL-3和VEGF与肿瘤分化、侵袭、转移和预后不良密切相关。
Objective: To investigate the expression and clinical significance of PRL-3 and VEGF in colon cancer tissues. METHODS: Immunohistochemical technique was used to detect the expression of PRL-3 and VEGF in 50 cases of colon cancer tissues and their adjacent tissues. The relationship between the expression of PRL-3 and VEGF and the clinicopathologic variables was analyzed. RESULTS: The expression of PRL-3 and VEGF in colon cancer tissues was significantly higher than that in adjacent tissues, which was statistically significant. The positive expression rates of PRL-3 and VEGF were related to tumor differentiation, lymph node metastasis, and TNM staging. However, it was not related to age, gender, and tumor size (P>0.05). The median survival time of PRL-3 and VEGF upregulated individuals was significantly shorter than those with low expression. There was a significant correlation between PRL-3 and VEGF expression. Conclusion: PRL-3 and VEGF are closely related to tumor differentiation, invasion, metastasis and poor prognosis.