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新型强心药Sulmazole(碱或盐酸盐)1mg/kg i.v,对麻醉止常猫和心衰猫均能显著增加dp/dtmax,LVSP;而HR增加不明显。在心衰猫能显著增加CO,降低LVEDP。在麻醉猫可持久降低MAP,并呈剂量依赖关系。心衰猫则升高MAP。dp/dt max增加值分别为7％(正常猫、碱),13％(正常猫、盐)和45％(心衰猫、碱)。出现心律异常的剂量分别为10mg/kg(正常猫、碱;3/12只)、10mg/kg(正常猫、盐;2/~7只)和20mg/kg(心衰猫、碱;3/11只),并呈可逆性。增至30mg/kg(碱)时在正常猫引起严重心律失常,但无一动物死亡。中毒量与有效量之比为10～30。 Ouabain30μg/kg i.v,对麻醉猫显著增加dp/dt max(13％)、LVSP、MAP,减慢HR。d5Pg/kg i.v已出现心律异常(3/8只)。60μg/kg i.v大部份动物(6/8只)出现严重不可逆性心律失常而致死。中毒量与有效量之比低于2。
The new cardiac drug Sulmazole (alkali or hydrochloride) 1mg / kg i.v, can significantly increase dp / dtmax, LVSP; while the increase of HR is not obvious. Cats in the heart failure can significantly increase CO, reduce LVEDP. In anesthetized cats, MAP can be reduced permanently and in a dose-dependent manner. Heart failure cats are elevated MAP. The dp / dt max added values were 7% (normal cats, bases), 13% (normal cats, salt) and 45% (heart failure cats, bases) respectively. The rates of abnormal heart rhythm were 10 mg / kg (normal cats and bases; 3/12 animals), 10 mg / kg (normal cats, salt; 2 / -7 animals) and 20 mg / 11), and was reversible. Increases to 30 mg / kg (base) caused severe arrhythmias in normal cats, but none of the animals died. Poisoning amount and the effective amount of 10 to 30. Ouabain at 30 μg / kg i.v significantly increased dp / dt max (13%), LVSP, MAP, and HR in anesthetized cats. D5Pg / kg i.v has abnormal heart rhythm (3/8 only). 60μg / kg i.v Most animals (6/8) died of serious irreversible arrhythmia. Toxicity and effective amount of less than 2.